| Date | Location | Result | |
| Nov 27, 2021 | Whitewater, Wisconsi | Wis.-Whitewater 45, DePauw 0 | |
| Nov 20, 2021 | Greencastle, Indiana | DePauw 26, Rose-Hulman 21 | |
| 11/13/2021 | Springfield, OH | Wittenberg 44, Wooster 29 | |
| Nov 13, 2021 | Crawfordsville, Indi | Wabash 42, DePauw 35 | |
| Nov 13, 2021 | Gambier, Ohio | Kenyon 21, Hiram 16 | |
| Nov 13, 2021 | Granville, Ohio | Ohio Wesleyan 35, Denison 25 | |
| 11/13/2021 | Meadville, Pa. | Allegheny 42, Oberlin 38 | |
| Nov 06, 2021 | Wooster, Ohio | Wooster 59, Allegheny 41 | |
| Nov 06, 2021 | Crawfordsville, Indi | Wittenberg 35, Wabash 14 | |
| Nov 6, 2021 | Delaware, Ohio, USA | Ohio Wesleyan 52, Kenyon 17 | |
| Nov 06, 2021 | Hiram, Ohio | Denison 59, Hiram 6 | |
| Nov 06, 2021 | Greencastle, Indiana | DePauw 66, Oberlin 13 | |
| Oct 30, 2021 | Wooster, Ohio | Wooster 51, Hiram 14 | |
| Oct 30, 2021 | Gambier, Ohio | Wabash 59, Kenyon 34 | |
| Oct 30, 2021 | Greencastle, Indiana | DePauw 27, Denison 10 | |
| 10/30/2021 | Meadville, Pa. | Wittenberg 29, Allegheny 19 | |
| 10/23/2021 | Springfield, OH | Wittenberg 38, Kenyon 14 | |
| Oct 23, 2021 | Delaware, Ohio, USA | Ohio Wesleyan 35, Wabash 28 | |
| Oct 23, 2021 | Hiram, Ohio | Oberlin 31, Hiram 28 | |
| Oct 23, 2021 | Granville, Ohio | Denison 52, Wooster 28 | |
| 10/23/2021 | Meadville, Pa. | DePauw 38, Allegheny 14 | |
| Oct 16, 2021 | Crawfordsville, Indi | Wooster 44, Wabash 41 | |
| Oct 16, 2021 | Oberlin, OH | Wittenberg 44, Oberlin 27 | |
| Oct 16, 2021 | Gambier, Ohio | Denison 45, Kenyon 7 | |
| Oct 16, 2021 | Hiram, Ohio | Allegheny 38, Hiram 13 | |
| Oct 16, 2021 | Greencastle, Indiana | DePauw 24, Ohio Wesleyan 7 | |
| 10/9/2021 | Springfield, OH | DePauw 17, Wittenberg 14 | |
| Oct 09, 2021 | Crawfordsville, Indi | Wabash 49, Oberlin 20 | |
| Oct 9, 2021 | Delaware, Ohio, USA | Ohio Wesleyan 34, Hiram 17 | |
| Oct 07, 2021 | Granville, Ohio | Wabash 39, Denison 38 | |
| Oct 2, 2021 | Delaware, Ohio, USA | Wittenberg 24, Ohio Wesleyan 23 | |
| Oct 02, 2021 | Oberlin, Ohio | Wooster 28, Oberlin 24 | |
| Oct 02, 2021 | Greencastle, Indiana | DePauw 57, Hiram 7 | |
| 10/2/2021 | Meadville, Pa. | Kenyon 27, Allegheny 13 | |
| Sep 25, 2021 | Wooster, | DePauw 34, Wooster 30 | |
| Sep 25, 2021 | Gambier, Ohio | Kenyon 24, Oberlin 21 | |
| Sep 25, 2021 | Granville, Ohio | Denison 21, Wittenberg 16 | |
| 9/25/2021 | Meadville, Pa. | Ohio Wesleyan 28, Allegheny 19 | |
| 9/18/2021 | Springfield, OH | Wittenberg 51, Hiram 21 | |
| Sep 18, 2021 | Crawfordsville, Indi | Wabash 36, Allegheny 28 | |
| Sep 18, 2021 | Delaware, Ohio, USA | Ohio Wesleyan 31, Wooster 7 | |
| Sep 18, 2021 | Oberlin , OH | Denison 59, Oberlin 12 | |
| Sep 18, 2021 | Greencastle, Indiana | DePauw 44, Kenyon 0 | |
| Sep 11, 2021 | Wooster, | Wooster 49, Kenyon 7 | |
| Sep 11, 2021 | Oberlin, Ohio | Ohio Wesleyan 62, Oberlin 6 | |
| Sep 11, 2021 | Hiram, Ohio | Wabash 42, Hiram 14 | |
| Sep 11, 2021 | Indianapolis, Ind. | Butler 49, DePauw 24 | |
| Sep 11, 2021 | Granville, Ohio | Denison 31, Allegheny 0 | |
| Sep 04, 2021 | Wooster, Ohio | Wooster 42, Geneva 35 | |
| 9/4/2021 | Springfield, OH | Cortland 38, Wittenberg 16 | |
| Sep 04, 2021 | Terre Haute, Indiana | Wabash 33, Rose-Hulman 23 | |
| Sep 04, 2021 | Westerville, Ohio | Ohio Wesleyan 32, Otterbein 28 | |
| Sep 04, 2021 | Oberlin, Ohio | Kalamazoo College 24, Oberlin 17 | |
| Sep 04, 2021 | Gambier, Ohio | Benedictine (IL) 34, Kenyon 31 | |
| Sep 04, 2021 | Ada, Ohio | Ohio Northern 34, Denison 10 | |
| 9/4/2021 | Meadville, Pa. | Allegheny 42, Thiel 14 | |
| Sep 03, 2021 | Hiram, Ohio | Hiram 41, Bethany (WV) 21 |